CA16119 – In vitro 3-D total cell guidance and fitness

Почеток-Крај: 2017-2021

Број на COST Акција: CA16119

Име на COST Акцијата: In vitro 3-D total cell guidance and fitness

Веб страница-Линк:

Краток опис:

CellFit is a European network of excellence (CA16119), with competence on all levels within fundamental biology, bio-engineering as well as clinical research. CellFit aims to translate the present basic knowledge in cell control, cell repair and regeneration from the laboratory bench to the clinical application. Furthermore, CellFit will create synergies, optimize the use of human and financial resources and foster the value of ex vivo models for European R&D operations.

CellFit aims to refine our understanding of the “in vivo” microenvironment, reduce the differences when translating it “in vitro”, to create 3-D total guidance ex vivo culture systems for the replacement of animal use. This will be achieved by bringing together researchers and biotechnology companies from different European countries, who are currently working on various aspects of the specific models that will be enforced in the present research.

The programme of CellFit is focusing on a more refined understanding of the natural
tissue environment with a specific emphasis to the existing 3-dimensional (3-D) organ and tissue architecture as well as to the local gradient both of chemical and mechanical types. Based on the acquired information, it will be possible to define complex ex vivo culture systems that may successfully replace the inefficient, low physiological 2-D in vitro models that typically provide a static environment, with homogenous cell populations, cultured on two-dimensional (2-D) plastic or glass substrates. We feel that this aspect may constitute a severe limit for our present understanding of many biological processes in development, tissue homeostasis as well as disease, since it recapitulates the physiological behaviour of cells insufficiently. This Action will develop useful tools to exploit environmental cues to drive cells towards a specific fate, thereby mimicking cell guidance conditions as they occur in vivo. This will allow designing of more physiological models.

Преставници на ФВМС и нивна Улога во COST акцијата:

проф. д-р Тони Довенски, Член на Менаџмент Комитетот;